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Updated: Mar 7, 2026

Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents
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Calcium-mediated cellular triggered activity in atrial fibrillation

Dobromir Dobrev1,2, Xander H T Wehrens2,3

  • 1Institute for Pharmacology, West German Heart and Vascular Centre, University Duisburg-Essen, Essen, Germany.

The Journal of Physiology
|February 10, 2017
PubMed
Summary

Atrial fibrillation (AF) mechanisms are unclear, but altered intracellular calcium handling, particularly ryanodine receptor type 2 (RyR2) dysfunction, causes triggered activity. This review explores calcium

Keywords:
arrhythmiaatrial fibrillationcalciumryanodine receptortriggered activity

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