Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

245
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
245
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

2.2K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.2K
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

304
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
304
Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

935
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
935
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

6.3K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
6.3K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

6.2K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dysregulated growth hormone-insulin-like growth factor-1 axis in adults with metabolic dysfunction-associated steatotic liver disease: a meta-analysis.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2026
Same author

Letter to the editors.

Inflammatory bowel diseases·2026
Same author

Chronic infection and metabolic stress: a converging axis driving hypertension and MASLD outcomes.

American journal of hypertension·2026
Same author

Non-invasive imaging diagnostic techniques in metabolic dysfunction-associated steatotic liver disease: a roadmap for clinicians.

Hormones (Athens, Greece)·2026
Same author

Impact of Helicobacter pylori- and Porphyromonas gingivalis-associated metabolic syndrome on local and systemic disorders.

Neuro endocrinology letters·2026
Same author

Helicobacter pylori and Porphyromonas gingivalis as risk factors for local oral and systemic disorders.

Clinical oral investigations·2026

Related Experiment Video

Updated: Mar 7, 2026

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

1.9K

Thyroid dysfunction and non-alcoholic fatty liver disease.

Zoe A Efstathiadou1, Marina D Kita2, Stergios A Polyzos2

  • 1Department of Endocrinology, Hippokration General Hospital, Thessaloniki, Greece - zefsta@endo.gr.

Minerva Endocrinologica
|February 10, 2017
PubMed
Summary
This summary is machine-generated.

Thyroid hormones impact liver metabolism. This review explores the contradictory link between thyroid function and non-alcoholic fatty liver disease (NAFLD) and potential thyromimetic treatments.

More Related Videos

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

1.9K
Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution
04:14

Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution

Published on: April 16, 2019

12.8K

Related Experiment Videos

Last Updated: Mar 7, 2026

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

1.9K
Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

1.9K
Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution
04:14

Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution

Published on: April 16, 2019

12.8K

Area of Science:

  • Endocrinology
  • Hepatology
  • Metabolic Diseases

Background:

  • Thyroid hormones regulate hepatic lipid and glucose metabolism.
  • Non-alcoholic fatty liver disease (NAFLD) shares features with hypothyroidism, including obesity and insulin resistance.
  • Hypothyroidism prevalence is higher in NAFLD patients, but the thyroid-NAFLD relationship is debated.

Purpose of the Study:

  • To review observational data on thyroid hormone levels and NAFLD.
  • To discuss the evidence for treating NAFLD with thyroid hormone analogues.
  • To clarify the association between thyroid function and NAFLD incidence/severity.

Main Methods:

  • Review of observational studies.
  • Analysis of existing literature on thyroid hormone analogues for NAFLD.
  • Synthesis of data on metabolic regulation by thyroid hormones.

Main Results:

  • The relationship between thyroid hormone levels (within or near reference ranges) and NAFLD is contradictory.
  • Thyroid hormone analogues are in early stages of investigation for NAFLD treatment.
  • Thyroid dysfunction is linked to metabolic derangements seen in NAFLD.

Conclusions:

  • Further research is needed to elucidate the thyroid-NAFLD connection.
  • Thyroid hormone analogues show potential but require more study for NAFLD therapy.
  • Understanding thyroid hormone's role is key for managing NAFLD.