Versicoamides F-H, Prenylated Indole Alkaloids from Aspergillus tennesseensis
Li Liu1,2, Long Wang1, Li Bao1,2
1State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing, 100101, People's Republic of China.
Abstract:
Three highly modified indole alkaloids, versicoamides F-H (1-3), together with seven known alkaloids (4-10) were isolated from the fungus Aspergillus tennesseensis. The structures of new compounds were determined by analysis of the NMR and MS spectroscopic data. The absolute configurations of 1 and 2 were assigned by single-crystal X-ray diffraction experiments. Compounds 1 and 2 showed weak antiproliferative activity against the H460 cell line. Compounds 1-3 represent a new class of natural product hybrids with new chemical skeletons.
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