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Related Experiment Videos

Experimental aortic replacement with a vascularized tissue graft.

W H Coltharp1

  • 1Department of Surgery, University of Mississippi Medical Center, Jackson.

Archives of Surgery (Chicago, Ill. : 1960)
|November 1, 1989
PubMed
Summary
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Replacement of the canine infrarenal aorta with an autogenous, living, tissue graft.

Current surgery·1988

This study explored using vascularized muscle grafts for aortic replacement in dogs, finding them viable and patent long-term. This technique shows promise for preventing prosthetic graft infection in aortic surgery.

Area of Science:

  • Vascular Surgery
  • Regenerative Medicine
  • Biomaterials Engineering

Background:

  • Prosthetic graft infection is a severe complication in aortic replacement surgery.
  • Current prosthetic grafts are susceptible to infection, leading to catastrophic outcomes.
  • There is a need for infection-resistant aortic graft materials.

Purpose of the Study:

  • To investigate the feasibility of using a vascularized, musculofascial pedicle graft for infrarenal aortic replacement in a canine model.
  • To assess the patency and histological characteristics of these grafts over time.

Main Methods:

  • Eight dogs underwent infrarenal aortic replacement using a vascularized pedicle graft constructed from the rectus abdominus muscle, sheath, and peritoneum, based on the inferior epigastric artery.

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  • Graft patency was evaluated using aortography at multiple time points (immediately, 1, 6, and 10 months).
  • Gross and histological examinations were performed at one month to assess graft viability and tissue integration.

    • Main Results:

    • Aortography confirmed graft patency immediately and up to 10 months post-implantation.
    • Histological analysis at one month revealed viable skeletal muscle within the graft with minimal luminal fibrin deposition.
    • At 10 months, microscopic examination showed patent vessels within the graft and the development of a neoendothelial layer lining the lumen.

    Conclusions:

    • Successful replacement of the canine infrarenal aorta can be achieved using a vascularized, musculofascial pedicle graft.
    • The graft demonstrated long-term patency and histological evidence of tissue integration, including neoendothelialization.
    • This vascularized graft technique holds intriguing potential for use in infected fields, warranting further investigation.