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Published on: March 29, 2018
Biodegradable mesoporous delivery system for biomineralization precursors
Hong-Ye Yang1, Li-Na Niu2, Jin-Long Sun2
1The State Key Laboratory Breeding Base of Basic Science of Stomatology, Key Laboratory for Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, People's Republic of China.
Researchers developed a novel nanoscale scaffold using amorphous calcium phosphate (ACP) within mesoporous silica nanoparticles (pMSN). This innovative supplement enhances bone regeneration by promoting collagen mineralization and releasing beneficial silica, offering a safer alternative for bone repair.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Tissue Engineering
Background:
- Conventional scaffolds for hard tissue repair often use nanoparticles or growth factors.
- Concerns exist regarding the clinical side effects of high doses of recombinant bone-morphogenetic protein-2 in bone surgery.
- There is a need for multifunctional, osteoinductive nanoscale scaffold supplements as alternatives.
Purpose of the Study:
- To develop a novel, biodegradable nanoscale scaffold supplement for enhanced bone regeneration.
- To create a system for sustained release of amorphous calcium phosphate (ACP) and orthosilicic acid.
- To investigate the potential of poly(allylamine)-stabilized ACP loaded mesoporous silica nanoparticles (PAH-ACP/pMSN) as a versatile scaffold supplement.
Main Methods:
- Developed nonfunctionalized expanded-pore mesoporous silica nanoparticles (pMSN) as carriers.
- Loaded pMSN with a novel polyamine-stabilized liquid precursor phase of amorphous calcium phosphate (PAH-ACP).
- Evaluated the sustained release, collagen mineralization capability, degradation, and cytotoxicity of the PAH-ACP/pMSN system.
Main Results:
- PAH-ACP was effectively loaded into and released from pMSN.
- Released PAH-ACP demonstrated the ability to infiltrate and mineralize collagen fibrils.
- pMSN exhibited complete degradation after PAH-ACP unloading.
- PAH-ACP/pMSN showed low cytotoxicity towards human bone marrow-derived mesenchymal stem cells.
Conclusions:
- Biodegradable pMSN effectively deliver PAH-ACP for collagen biomineralization and orthosilicic acid release, promoting bone growth.
- The developed PAH-ACP/pMSN system is a versatile scaffold supplement for enhancing bone regeneration.
- This nanoparticle system presents a promising, safer alternative to high-dose recombinant bone-morphogenetic protein-2 in bone surgery.
