Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Simple microphthalmos.

A H Weiss1, B G Kousseff, E A Ross

  • 1Department of Ophthalmology, University of South Florida Medical Center, Tampa 33612.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|November 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A new malaria vector in Africa: Predicting the expansion range of <i>Anopheles stephensi</i> and identifying the urban populations at risk.

Proceedings of the National Academy of Sciences of the United States of America·2020
Same author

A multi-stop time-of-flight spectrometer for the measurement of positron annihilation-induced electrons in coincidence with the Doppler-shifted annihilation gamma photon.

The Review of scientific instruments·2020
Same author

Auger electron emission initiated by the creation of valence-band holes in graphene by positron annihilation.

Nature communications·2017
Same author

Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression.

Annals of the rheumatic diseases·2016
Same author

Time of flight spectrometer for background-free positron annihilation induced Auger electron spectroscopy.

The Review of scientific instruments·2016
Same author

Esophageal motility in eosinophilic esophagitis.

Revista de gastroenterologia de Mexico·2015
Same journal

The economics of the initial preventive physical examination in medicare-reply.

Archives of ophthalmology (Chicago, Ill. : 1960)·2013
Same journal

Modification of silicone oil retention sutures in aphakic eyes with iris loss-reply;.

Archives of ophthalmology (Chicago, Ill. : 1960)·2013
Same journal

December 2011 archives web quiz winner.

Archives of ophthalmology (Chicago, Ill. : 1960)·2013
Same journal

Angle involvement and glaucoma in patients with biopsy-proven iris melanoma: a response-reply.

Archives of ophthalmology (Chicago, Ill. : 1960)·2013
Same journal

About this journal.

Archives of ophthalmology (Chicago, Ill. : 1960)·2013
Same journal

In memoriam: goodwin m. Breinin, MD (1918-2011).

Archives of ophthalmology (Chicago, Ill. : 1960)·2013
See all related articles

Microphthalmos, a condition of small eye size, is often caused by disproportionately short posterior eye segments. This study analyzed axial lengths in 22 patients to understand its causes.

Area of Science:

  • Ophthalmology
  • Genetics
  • Developmental Biology

Background:

  • Microphthalmos is a congenital eye condition characterized by an abnormally small eyeball.
  • Understanding the etiological factors and developmental mechanisms of microphthalmos is crucial for diagnosis and potential interventions.

Purpose of the Study:

  • To investigate the axial length measurements in patients diagnosed with simple microphthalmos.
  • To determine the specific segment of the eye (anterior or posterior) that contributes most significantly to the reduced axial length in microphthalmos.
  • To identify potential underlying causes and associated conditions contributing to microphthalmos.

Main Methods:

  • Diagnosis of simple microphthalmos based on total axial length at least 2 standard deviations below the age-specific mean.

Related Experiment Videos

  • Analysis of anterior and posterior segment lengths in microphthalmic patients compared to age-similar controls.
  • Evaluation of associated systemic disorders in patients with microphthalmos.

    • Main Results:

    • Twenty-two patients were diagnosed with simple microphthalmos.
    • Posterior segment length was significantly reduced in all patients, indicating it's the primary cause of microphthalmos.
    • Ten patients had isolated microphthalmos, with one case meeting criteria for nanophthalmos.
    • Twelve patients had microphthalmos associated with systemic disorders like fetal alcohol syndrome and myotonic dystrophy.

    Conclusions:

    • Disproportionate reduction in posterior segment length is the main characteristic of simple microphthalmos.
    • Associated systemic disorders may play a role in the pathogenesis of microphthalmos through various biological mechanisms.
    • Further research into the genetic and molecular factors is warranted to elucidate the complex etiology of microphthalmos.