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Related Experiment Videos

Retinal oxalosis. A clinicopathologic report.

C G Wells1, R J Johnson, L Qingli

  • 1Department of Ophthalmology, University of Washington, School of Medicine, Seattle.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|November 1, 1989
PubMed
Summary

Systemic oxalosis caused severe vision loss in a hemodialysis patient due to retinal artery crystals. Contributing factors included renal failure, ascorbic acid, pyridoxine deficiency, and ileal resection.

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Area of Science:

  • Ophthalmology
  • Nephrology
  • Metabolic Disorders

Background:

  • Chronic renal failure and hemodialysis can predispose patients to metabolic complications.
  • Systemic oxalosis is a rare condition characterized by oxalate deposition in various organs.
  • Ocular manifestations of systemic oxalosis can lead to significant visual impairment.

Observation:

  • A 55-year-old woman on hemodialysis presented with severe bilateral visual loss.
  • Ophthalmoscopy revealed crystals within retinal arteries, indicative of retinal ischemia.
  • The clinical presentation and findings suggested a diagnosis of systemic oxalosis.

Findings:

  • Histopathology confirmed calcium oxalate deposition predominantly in the walls of retinal blood vessels.
  • Contributing factors identified were chronic renal failure, ascorbic acid supplementation, pyridoxine deficiency, and prior ileal resection.

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  • The ocular findings were directly linked to oxalate deposition in the retinal vasculature.

    • Implications:

    • This case highlights the importance of recognizing systemic oxalosis in patients with chronic kidney disease presenting with visual disturbances.
    • Identifying and managing contributing factors like ascorbic acid intake and nutritional deficiencies is crucial.
    • Early diagnosis and intervention may help prevent irreversible vision loss in susceptible individuals.