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Metronidazole and Norfloxacin Induced Generalized Fixed Drug Eruptions in an Adult Male Patient - a Case Report

Nidhi S Patel1, Bhavesh C Chavada1, Viren N Naik2

  • 1Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-364001, Gujarat,India.

Current Drug Safety
|February 11, 2017
PubMed
Abstract

Insights

Fixed drug eruptions (FDEs) can occur with fluoroquinolones like norfloxacin. Prompt recognition and management are crucial for patient recovery and preventing future reactions.

Area of Science:

  • Pharmacology
  • Dermatology
  • Internal Medicine

Background:

  • Fluoroquinolones are frequently used for gastrointestinal infections due to increasing antimicrobial resistance.
  • These antibiotics can cause cutaneous adverse drug reactions of varying severity.

Purpose of the Study:

  • To report a case of fixed drug eruptions (FDEs) caused by norfloxacin and metronidazole.
  • To highlight the importance of recognizing and managing FDEs.

Main Methods:

  • A case study of a 43-year-old male patient presenting with fixed drug eruptions.
  • Involved administration of norfloxacin and metronidazole for abdominal pain and diarrhea.
  • Management included cessation of causative agents and both local and systemic therapies.

Main Results:

  • The patient developed widespread erythematous rashes, including on the buccal mucosa.
  • Recovery was achieved within 20 days after discontinuation of the offending drugs and appropriate management.

Conclusions:

  • Fixed drug eruptions are a significant adverse reaction to fluoroquinolones.
  • Healthcare professionals must be aware of FDEs for timely diagnosis and management.
  • Patient counseling regarding potential drug reactions is essential to prevent recurrence.
Keywords:
Cross sensitivityFDE.empirical treatmentfixed drug eruptionsmetronidazolenorfloxacin

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