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Typhoid hepatitis: two case reports.

B A Mahmood

    Bangladesh Medical Research Council Bulletin
    |June 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    This report details two cases of typhoid hepatitis, a rare complication of Salmonella Typhi infection. Prompt diagnosis and chloramphenicol treatment led to full recovery in both patients.

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    Area of Science:

    • Hepatology
    • Infectious Diseases
    • Gastroenterology

    Background:

    • Typhoid hepatitis is an uncommon manifestation of Salmonella Typhi infection.
    • Early recognition is crucial for effective management and preventing complications.

    Observation:

    • Two patients presented with classic typhoid symptoms including jaundice, high fever, toxaemia, and hepatomegaly.
    • Clinical presentation also included abdominal distension and diarrhoea.
    • Abnormal liver function tests and high Widal titres were noted in both cases.

    Findings:

    • Blood cultures confirmed Salmonella Typhi in both patients, establishing the diagnosis of typhoid hepatitis.
    • Both patients received chloramphenicol therapy.
    • Uneventful recovery was achieved in both cases following treatment.

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    Implications:

    • This case series highlights the importance of considering typhoid hepatitis in the differential diagnosis of acute jaundice, especially in endemic areas.
    • Chloramphenicol remains an effective treatment for typhoid hepatitis.
    • Further research into the pathogenesis and optimal management strategies for typhoid hepatitis is warranted.