Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Pressure Imbalances and Circulatory Shock01:24

Blood Pressure Imbalances and Circulatory Shock

1.8K
Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
1.8K
Introduction to Hemostasis01:05

Introduction to Hemostasis

15.6K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
15.6K
Disorders of Hemostasis01:24

Disorders of Hemostasis

2.6K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
2.6K
Vascular Spasm01:16

Vascular Spasm

4.4K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
4.4K
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

14.4K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
14.4K
Coagulation01:09

Coagulation

11.4K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
11.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[In-hospital sepsis screening].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2025
Same author

[Intraoperative clinical application of hemodynamic monitoring in noncardiac surgery patients].

Die Anaesthesiologie·2024
Same author

[Puzzling B symptoms in a 61-year-old patient under treatment for rheumatoid arthritis].

Der Internist·2021
Same author

[Inhaled budesonide in the treatment of COVID-19].

Der Internist·2021
Same author

[Pharmacological/pharmaceutical counseling in intensive care medicine].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2021
Same author

[S2k Guideline - Recommendations for Inpatient Therapy of Patients with COVID-19].

Pneumologie (Stuttgart, Germany)·2021

Related Experiment Video

Updated: Mar 7, 2026

Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs
07:51

Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs

Published on: May 21, 2019

7.9K

[Hemorrhagic shock : General principles].

T I Eiben1, V Fuhrmann2, B Saugel3

  • 1Klinik für Intensivmedizin, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland. teiben@uke.de.

Der Internist
|February 11, 2017
PubMed
Summary
This summary is machine-generated.

Effective hemorrhagic shock management requires prompt bleeding identification and tailored initial therapy for hemodynamic stabilization and coagulation. Careful fluid administration and treatment of acidosis and hypothermia are crucial, alongside continuous clotting monitoring.

Keywords:
Acidosis, lacticBlood coagulationFluid therapyHemodynamicsHypothermia

More Related Videos

Author Spotlight: Developing Innovative Therapeutic Strategies for Hemorrhagic Shock Research
08:14

Author Spotlight: Developing Innovative Therapeutic Strategies for Hemorrhagic Shock Research

Published on: March 22, 2024

2.1K
Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
16:31

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Published on: June 6, 2011

25.7K

Related Experiment Videos

Last Updated: Mar 7, 2026

Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs
07:51

Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs

Published on: May 21, 2019

7.9K
Author Spotlight: Developing Innovative Therapeutic Strategies for Hemorrhagic Shock Research
08:14

Author Spotlight: Developing Innovative Therapeutic Strategies for Hemorrhagic Shock Research

Published on: March 22, 2024

2.1K
Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
16:31

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Published on: June 6, 2011

25.7K

Area of Science:

  • Emergency Medicine
  • Critical Care Medicine
  • Trauma Surgery

Background:

  • Hemorrhagic shock is a critical condition frequently encountered in emergency medical services and intensive care units.
  • Accurate identification of bleeding sources and associated disorders is essential for assessing shock severity.

Purpose of the Study:

  • To outline effective initial therapeutic strategies for hemorrhagic shock management prior to the availability of blood products.
  • To emphasize the importance of differentiating therapies for hemodynamic stabilization and coagulation support.

Main Methods:

  • Review of current clinical practices and evidence-based guidelines for hemorrhagic shock management.
  • Discussion of the risks associated with crystalloid and colloid solutions.
  • Emphasis on the role of acidosis and hypothermia treatment.
  • Highlighting the necessity of early and repeated coagulation monitoring.

Main Results:

  • Initial therapy must focus on hemodynamic stabilization and supporting coagulation.
  • Cautious use of crystalloid and colloid solutions is advised due to inherent risks.
  • Addressing acidosis and hypothermia can mitigate bleeding complications.
  • Simultaneous shock therapy and clotting monitoring allow for timely, specific interventions and factor substitution.

Conclusions:

  • Hemorrhagic shock management necessitates a multi-faceted approach including source control, judicious fluid resuscitation, and correction of metabolic derangements.
  • Continuous monitoring of coagulation status is paramount for guiding therapy and ensuring adequate factor replacement.
  • Therapeutic interventions should persist until active bleeding is effectively controlled.