Association between the hypertriglyceridemic waist phenotype and hyperuricemia: a cross-sectional study

Area of Science:

• Metabolic Health
• Cardiovascular Risk Factors
• Endocrinology

Background:

• Hypertriglyceridemic waist (HTGW) phenotype is associated with metabolic syndrome.
• Hyperuricemia is linked to cardiovascular and metabolic diseases.
• Understanding the relationship between HTGW and hyperuricemia is crucial for risk stratification.

Purpose of the Study:

• To investigate the association between the hypertriglyceridemic waist (HTGW) phenotype and hyperuricemia.
• To determine if the HTGW phenotype is an independent risk factor for hyperuricemia.

Main Methods:

• Cross-sectional study of 11,576 adults in China.
• HTGW phenotype defined by elevated waist circumference and triglyceride levels.
• Logistic regression analysis to assess the association with hyperuricemia.

Main Results:

• Prevalence of hyperuricemia was significantly higher in the HTGW group (25.9%) compared to the normal waist normal triglyceride group (6.1%).
• The HTGW phenotype was strongly associated with hyperuricemia (OR 6.09, 95% CI 5.18-7.17), even after adjustments.
• The association was stronger in men than in women.

Conclusions:

• The HTGW phenotype is significantly associated with hyperuricemia.
• HTGW phenotype may serve as a clinical marker for identifying individuals at high risk of hyperuricemia.
• Clinical monitoring of uric acid is advised for individuals with the HTGW phenotype.