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Neprilysin Inhibitors in Cardiovascular Disease

Guson Kang1, Dipanjan Banerjee2

  • 1Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Falk Cardiovascular Research Center, 870 Quarry Road, Palo Alto, CA, 94304, USA. guson@stanford.edu.

Current Cardiology Reports
|February 11, 2017
PubMed

Insights

New heart failure medications called Angiotensin receptor-neprilysin inhibitor (ARNI) combinations significantly reduce mortality. These advanced treatments are now recommended for patients with heart failure and reduced ejection fraction.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Despite medical advances, heart failure mortality remains a significant clinical challenge.
  • Established treatments include beta blockers, ACE inhibitors/ARBs, and aldosterone antagonists.

Purpose of the Study:

  • To evaluate the impact of Angiotensin receptor-neprilysin inhibitor (ARNI) combinations on heart failure mortality.

Main Methods:

  • Analysis of recent clinical trial data on ARNI efficacy in heart failure patients.

Main Results:

  • Recent trial data demonstrate a significant mortality benefit associated with ARNI use.
  • Major cardiology societies issued a Class I recommendation for ARNIs in May 2016.

Conclusions:

  • Angiotensin receptor-neprilysin inhibitor (ARNI) combinations represent a significant advancement in heart failure management.
  • These agents offer a mortality benefit for patients with heart failure and reduced ejection fraction.

Keywords:
Heart failureLCZ696Neprilysin inhibitorSacubitril

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