Cytophotometric and cytogenetic analyses of mouse lymphomas

Simultaneous cytophotometric and cytogenetic analyses of spontaneous mesenteric lymphomas from three female mice are reported. No statistically significant deviation from normal lymph node cells could be detected for any of the tumors with respect to nucleic acid content. However, all three tumors demonstrated trisomy as the major cytogenetic anomaly. Chromosome 7 or 8 was found to be the extra chromosome in two of the lymphomas while identification of chromosomes was not possible in the third.