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Mitochondrial Complex II: At the Crossroads.

Ayenachew Bezawork-Geleta1, Jakub Rohlena2, Lanfeng Dong1

  • 1School of Medical Science, Griffith University, Southport, Australia.

Trends in Biochemical Sciences
|February 11, 2017
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Summary
This summary is machine-generated.

Mitochondrial complex II (succinate dehydrogenase, SDH) is crucial for metabolic adaptation. Aberrations in SDH function are linked to diseases, highlighting its potential as a therapeutic target for conditions like cancer.

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Area of Science:

  • Biochemistry
  • Cellular Metabolism
  • Molecular Biology

Background:

  • Mitochondrial complex II (succinate dehydrogenase, SDH) plays a key role in metabolic and respiratory adaptation.
  • SDH function is influenced by various intrinsic and extrinsic factors and cellular abnormalities.

Purpose of the Study:

  • To review recent findings on SDH biogenesis and activity modulation.
  • To explore the role of genetic and epigenetic aberrations in SDH dysfunction and associated diseases.
  • To discuss the emerging role of SDH in inflammation-linked pathologies.

Main Methods:

  • Literature review of recent findings on SDH.
  • Analysis of SDH biogenesis and assembly factors.
  • Examination of post-translational modifications (acetylation, succinylation, phosphorylation, proteolysis) affecting SDH activity.
  • Investigation of genetic and epigenetic alterations impacting SDH function.
  • Review of SDH's role in inflammation and disease.

Main Results:

  • SDH biogenesis requires four known assembly factors.
  • SDH enzymatic activity is modulated by acetylation, succinylation, phosphorylation, and proteolysis.
  • Genetic and epigenetic aberrations lead to SDH dysfunction and clinical manifestations.
  • SDH is implicated in inflammation-linked pathologies.

Conclusions:

  • SDH is a critical enzyme in cellular adaptation and disease.
  • Dysfunctional SDH, due to genetic or epigenetic changes, is associated with various clinical conditions.
  • SDH represents a potential therapeutic target for hard-to-treat diseases, including cancer.