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Fabrication of letrozole formulation using chitosan nanoparticles through ionic gelation method
Thandapani Gomathi1, P N Sudha1, J Annie Kamala Florence2
1Department of Chemistry, D.K.M. College for Women, Vellore, Tamil Nadu, India.
International Journal of Biological Macromolecules
|February 11, 2017
Summary
This study developed letrozole (LTZ) loaded chitosan nanoparticles (CS-NPs) for cancer treatment. The nanoformulation demonstrated biocompatibility and hemocompatibility, showing potential as an effective pharmaceutical excipient.
Area of Science:
- Materials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Letrozole (LTZ) is an anticancer drug.
- Chitosan nanoparticles (CS-NPs) offer potential for drug delivery.
- Optimizing nanoformulations is crucial for drug efficacy.
Purpose of the Study:
- To formulate and characterize letrozole-loaded chitosan nanoparticles (LTZ-CS-NPs).
- To evaluate the in vitro properties of the developed nanoformulation.
Main Methods:
- Chitosan nanoparticles (CS-NPs) were prepared using sodium tripolyphosphate (TPP) as a crosslinker.
- Drug loading was optimized by varying letrozole concentration.
- Characterization included FTIR, TGA, XRD, SEM, TEM, and DLS.
- In vitro studies assessed hemocompatibility, biodegradability, and serum stability.
Main Results:
- FTIR confirmed the successful formation of LTZ-CS-NPs.
- TEM revealed particle sizes of 60-80nm (air-dried) and 20-40mm (freeze-dried).
- The formulation exhibited biocompatibility and hemocompatibility.
Conclusions:
- Chitosan nanoparticles are a suitable carrier for letrozole.
- The developed LTZ-CS-NPs possess favorable biocompatibility and hemocompatibility.
- This nanoformulation shows promise as an effective pharmaceutical excipient for letrozole delivery.
