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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
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Improving the dissolution properties of curcumin using dense gas antisolvent technology.
Firman Kurniawansyah1, Lisa Quachie2, Raffaella Mammucari3
1School of Chemical Engineering, University of New South Wales, Sydney 2052 NSW, Australia; Department of Chemical Engineering, Institute of Technology Sepuluh Nopember, Surabaya, Indonesia.
International Journal of Pharmaceutics
|February 11, 2017
Summary
Poor curcumin dissolution is improved using the atomized rapid injection solvent extraction (ARISE) system. This novel formulation method enhances curcumin bioavailability by creating micro-composites with superior solubility and dissolution profiles.
Area of Science:
- Pharmacology
- Materials Science
- Chemical Engineering
Background:
- Curcumin exhibits poor solubility, limiting its therapeutic applications.
- Developing effective curcumin formulations is crucial for enhancing bioavailability.
Purpose of the Study:
- To improve the dissolution properties and bioavailability of curcumin.
- To evaluate the efficacy of the atomized rapid injection solvent extraction (ARISE) system for curcumin formulation.
Main Methods:
- Curcumin was formulated with methyl-β-cyclodextrin and polyvinylpyrrolidone using the ARISE system.
- Co-precipitation was achieved using carbon dioxide as an anti-solvent at 30°C and 95bar.
- Comparative formulations were prepared via physical mixing and freeze drying.
Main Results:
- The ARISE process yielded curcumin micro-composites with significantly enhanced dissolution profiles.
- Characterization revealed differences in morphology, crystallinity, and molecular interactions compared to other methods.
- ARISE-prepared curcumin demonstrated superior apparent solubility and dissolution rates.
Conclusions:
- The ARISE system is an effective method for preparing curcumin micro-composites.
- This approach successfully overcomes the poor dissolution limitations of curcumin.
- Enhanced curcumin formulations via ARISE hold promise for improved bioavailability and therapeutic efficacy.
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