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A structure-activity relationship study of ABCC2 inhibitors

Gloria Wissel1, Feng Deng1, Pavel Kudryavtsev1

  • 1Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|February 11, 2017
PubMed
Summary

New compounds were tested for interaction with multidrug resistance associated protein 2 (MRP2/ABCC2). Structural features like aromaticity, lipophilicity, and halogen substitutions significantly influence MRP2/ABCC2 inhibitory activity.

Keywords:
MRP2ModulatorPharmacophoreTransporterVesicle assay

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