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Updated: Mar 7, 2026
09:37
Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
Published on: August 1, 2018
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Altered circadian hemodynamic and renal function in cirrhosis
Suthat Liangpunsakul1,2, Rajiv Agarwal2,3
1Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Summary
Cirrhosis patients show altered daily blood pressure and kidney function, potentially linked to endotoxemia. Further research is needed to confirm this causal relationship.
Area of Science:
- Nephrology
- Cardiovascular Physiology
- Hepatology
Background:
- Systemic hemodynamics significantly impact renal function in cirrhosis.
- Circadian variations in blood pressure (BP) and renal electrolyte excretion are understudied in cirrhosis.
Purpose of the Study:
- Define the relationship between 24-hour ambulatory BP and renal tubular function in cirrhosis.
- Determine the influence of endotoxemia on BP and urinary parameters in cirrhosis.
Main Methods:
- 24-hour ambulatory BP monitoring and urine collection in 20 cirrhotic patients and 40 healthy controls.
- Assessed diurnal variations in urinary sodium and creatinine excretion.
- Correlated BP changes with cirrhosis severity and endotoxemia.
Main Results:
- Cirrhotic patients exhibited altered diurnal urinary excretion of sodium and creatinine.
- Increasing cirrhosis severity correlated with reduced ambulatory BP and blunted BP diurnal variation.
- Endotoxemia was associated with decreased awake sodium excretion, lower awake systolic BP, and higher sleeping pulse rate.
Conclusions:
- Cirrhosis is associated with altered diurnal profiles of renal tubular function and blood pressure.
- These alterations may be linked to endotoxemia.
- Interventional studies are required to establish a causal relationship between endotoxemia and these perturbations.
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