[Mutations of mitochondrial tRNA^Ser(UCN) and their connection with hearing loss]

Mitochondrial tRNA^Ser(UCN) gene mutation is closely related to acoustic nerve deafness. Some mutations can affect the structure and transcriptional processing of tRNA^Ser(UCN), for instance m.7444G>A mutation in tRNA^Ser(UCN) precursor 3' side, m.7472 insC as well as m.7511T>C mutations in the stem and ring of tRNA^Ser(UCN), may influence tRNA^Ser(UCN) stability, thus affect the synthesis of mitochondrial peptides, reduce the production of ATP and cause deafness. This article focuses on mitochondrial tRNA^Ser(UCN) gene mutations as well as the mechanism underlying hearing loss.