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PDGFRA Antibody for Soft Tissue Sarcoma
Lillian R Klug1, Michael C Heinrich1
1Portland VA Health Care System and OHSU Knight Cancer Institute, Portland, OR 97239, USA.
Abstract:
Lartruvo (olaratumab) is a monoclonal antibody against the extracellular domain of PDGFRA. Olaratumab blocks ligand binding and thereby inhibits activation of PDGFRA kinase activity. Pre-clinically, this antibody inhibited PDGFRA-dependent tumor growth. In a randomized Phase II study, adding olaratumab to doxorubicin chemotherapy significantly improved overall survival, leading to FDA approval.
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