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Suppression by gamma-hydroxybutyric acid of ethanol withdrawal syndrome in rats

F Fadda1, G Colombo, E Mosca

  • 1Institute of Physiology, University of Cagliari, Italy.

Alcohol and Alcoholism (Oxford, Oxfordshire)
|January 1, 1989
PubMed

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Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...