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Published on: July 2, 2013
Impact of rTMS on functional connectivity within the language network in schizophrenia patients with auditory
F Briend1, E Leroux1, N Delcroix2
1Imagerie et Stratégies Thérapeutiques de la Schizophrénie (ISTS), Normandie Univ, UNICAEN, Faculté de médecine, Caen F-14000, France.
Abstract:
This exploratory study investigated the functional connectivity (FC) in the language network in schizophrenia patients (SZ) with auditory verbal hallucinations (AVHs), and the therapeutic efficacy of rTMS on it. Eleven SZ with AVHs and 10 healthy controls (HC) underwent two fMRI sessions using a speech listening paradigm. SZ received 20Hz rTMS following the first fMRI session. Compared to HC, SZ showed a reduced FC in the language network. While AVHs improved after 12days, no changes in FC were observed. This suggests the efficacy of high-frequency rTMS on AVH without any impact for rTMS on FC within the language network.

