Related Experiment Video
Updated: Mar 7, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Multilayered and digitally structured presentation formats of trustworthy recommendations: a combined survey and
Linn Brandt1,2, Per Olav Vandvik1,2, Pablo Alonso-Coello3,4
1Department of Internal Medicine, Sykehuset Innlandet Hospital Trust, Gjøvik, Norway.
Objectives:
To investigate practicing physicians' preferences, perceived usefulness and understanding of a new multilayered guideline presentation format-compared to a standard format-as well as conceptual understanding of trustworthy guideline concepts.
Design:
Participants attended a standardised lecture in which they were presented with a clinical scenario and randomised to view a guideline recommendation in a multilayered format or standard format after which they answered multiple-choice questions using clickers. Both groups were also presented and asked about guideline concepts.
Setting:
Mandatory educational lectures in 7 non-academic and academic hospitals, and 2 settings involving primary care in Lebanon, Norway, Spain and the UK.
Participants:
181 practicing physicians in internal medicine (156) and general practice (25).
Interventions:
A new digitally structured, multilayered guideline presentation format and a standard narrative presentation format currently in widespread use.
Primary And Secondary Outcome Measures:
Our primary outcome was preference for presentation format. Understanding, perceived usefulness and perception of absolute effects were secondary outcomes.
Results:
72% (95% CI 65 to 79) of participants preferred the multilayered format and 16% (95% CI 10 to 22) preferred the standard format. A majority agreed that recommendations (multilayered 86% vs standard 91%, p value=0.31) and evidence summaries (79% vs 77%, p value=0.76) were useful in the context of the clinical scenario. 72% of participants randomised to the multilayered format vs 58% for standard formats reported correct understanding of the recommendations (p value=0.06). Most participants elected an appropriate clinical action after viewing the recommendations (98% vs 92%, p value=0.10). 82% of the participants considered absolute effect estimates in evidence summaries helpful or crucial.
Conclusions:
Clinicians clearly preferred a novel multilayered presentation format to the standard format. Whether the preferred format improves decision-making and has an impact on patient important outcomes merits further investigation.
Related Concept Videos
Strategies of Self-Presentation I: Strategic Self-Presentation
Guidelines and Strategies for Safe Computer Charting
Maintain Confidentiality and Security:
Social Proof
Self-Presentation
Impression Management Techniques I: Managing Appearances
Processes of Self-Presentation
