Related Experiment Video
Updated: Mar 7, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
New Consensus Definitions for Sepsis and Septic Shock: Implications for Treatment Strategies and Drug Development?
Michael Berry1, Brijesh V Patel2,3, Stephen J Brett3,4
1Imperial School of Anaesthesia, London, UK. michael.berry@doctors.org.uk.
Abstract:
Sepsis continues to escape a precise diagnostic definition. The most recent consensus definition, termed Sepsis-3, highlights the importance of the maladaptive and potentially life-threatening host response to infection. After briefly reviewing the history and epidemiology of sepsis, we go on to describe some of the challenges encountered when classifying such a heterogenous disease state. In the context of these new definitions for sepsis and septic shock, we explore current and potentially novel therapies, and conclude by mentioning some of the controversies of this most recent framework.
Related Concept Videos
Blood Pressure Imbalances and Circulatory Shock
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions
Clinically Relevant Drug Product Specifications: Methods of Establishment
Acute Pyelonephritis II: Diagnostic Studies and Management
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Therapeutic Drug Monitoring: Overview and Classification

