Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.7K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.7K
Humoral Immune Responses01:36

Humoral Immune Responses

85.1K
Overview
85.1K
Development of Immunocompetence01:22

Development of Immunocompetence

1.1K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.1K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

85.4K
Overview
85.4K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

3.8K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
3.8K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.8K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neutralizing autoantibodies against IFN-α2 and IFN-ω in a boy with a heterozygous variant in the FOXN1 gene.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same author

Job's not done: BCG-itis as the first manifestation of hyper-IgE syndrome. A case report and review of the literature.

Clinical immunology (Orlando, Fla.)·2025
Same author

[Update on IgA vasculitis with a focus on diagnosis and prognosis in pediatrics].

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)·2025
Same author

Case Report: A novel <i>IKBKB</i> variant (c.1705G>T) is associated with immune dysregulation and disseminated tuberculosis.

Frontiers in immunology·2025
Same author

Chronic mucocutaneous candidiasis, mycobacterial infections and rosacea in a Mexican adult with STAT1 gain of function

Biomedica : revista del Instituto Nacional de Salud·2025
Same author

Analysis of B cell proliferation in response to in vitro stimulation in patients with CVID.

Allergologia et immunopathologia·2024

Related Experiment Video

Updated: Mar 7, 2026

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.9K

[Immunological alterations in common variable immunodeficiency].

Laura Berrón-Ruiz1

  • 1Secretaría de Salud, Instituto Nacional de Pediatría, Unidad de Investigación en Inmunodeficiencias. Ciudad de México, México. lberronruiz@yahoo.com.mx.

Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|February 12, 2017
PubMed
Summary
This summary is machine-generated.

Common variable immunodeficiency (CVID) involves immune system defects, leading to infections. Genetic research identifies mutations in key B and T cell genes, explaining CVID pathogenesis.

Keywords:
B cellsCommon variable immunodeficiencyInnate immune responsiveT cells

More Related Videos

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

2.9K
Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay
06:15

Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay

Published on: September 7, 2018

9.9K

Related Experiment Videos

Last Updated: Mar 7, 2026

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.9K
Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

2.9K
Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay
06:15

Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay

Published on: September 7, 2018

9.9K

Area of Science:

  • Immunology
  • Genetics

Background:

  • Common variable immunodeficiency (CVID) is a primary immune deficiency characterized by hypogammaglobulinemia, poor vaccine response, and recurrent infections.
  • Cellular phenotypes in CVID involve both adaptive and innate immune responses, with classifications based on T and B cell defects linked to clinical features.

Purpose of the Study:

  • To elucidate the genetic mechanisms underlying the Common variable immunodeficiency (CVID) phenotype.
  • To identify specific gene mutations contributing to CVID pathogenesis.

Main Methods:

  • Massive sequencing technologies were employed to identify mutations in patients with CVID.
  • Analysis focused on genes involved in B and T cell co-operation and intrinsic signaling pathways.

Main Results:

  • Genetic mutations were identified in 2% to 10% of CVID patients.
  • Identified genes include ICOS, TNFRSF13B (TACI), TNFRS13C (BAFFR), and others crucial for immune cell function.

Conclusions:

  • These genetic findings offer insights into the pathogenesis of CVID.
  • The identified mutations highlight the importance of specific molecules in B and T cell interactions and signaling pathways.