Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

6.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiac Modulation by <i>Santolina chamaecyparissus</i> Aqueous Extract in a Rat Model of Mammary Carcinogenesis.

Current issues in molecular biology·2026
Same author

Toxicological Activities of <i>Pteridium aquilinum</i> Rhizomes and Fiddleheads in HPV16-Transgenic Mice.

Biology·2026
Same author

The effects of long-term aerobic exercise on prostate cancer-induced adipose tissue wasting: Browning to the rescue?

Cellular signalling·2026
Same author

Strengthening animal welfare: monitoring humane endpoints in a rat model of mammary tumorigenesis undergoing a ladder resistance training protocol.

Laboratory animals·2026
Same author

Hepatic Mitochondrial Dysfunction and Gut Dysbiosis Induced by Polyethylene Microplastics in FVB/n Mice: A Comparative Study of Fluorescent and Non-Fluorescent Particles.

Toxics·2026
Same author

Biological evaluation of gelatin-based hemostatic agents - cytocompatibility and irritation assessment.

Dental and medical problems·2026

Related Experiment Video

Updated: Mar 7, 2026

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

7.2K

Experimental mammary carcinogenesis - Rat models.

Antonieta Alvarado1, Ana I Faustino-Rocha2, Bruno Colaço3

  • 1Área de Patología, Decanato de Ciencias Veterinarias, Universidad Centroccidental "Lisandro Alvarado", UCLA, Lara, Venezuela; Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal.

Life Sciences
|February 12, 2017
PubMed
Summary
This summary is machine-generated.

This review details rat models for studying mammary cancer, focusing on chemically-induced models to improve understanding and develop better therapies for this common disease.

Keywords:
Animal modelsChemical carcinogenesisMammary cancerRodents

More Related Videos

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
09:36

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

30.3K
Rat Mammary Epithelial Cell Transplantation into the Interscapular White Fat Pad
10:41

Rat Mammary Epithelial Cell Transplantation into the Interscapular White Fat Pad

Published on: March 4, 2020

8.3K

Related Experiment Videos

Last Updated: Mar 7, 2026

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

7.2K
Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
09:36

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

30.3K
Rat Mammary Epithelial Cell Transplantation into the Interscapular White Fat Pad
10:41

Rat Mammary Epithelial Cell Transplantation into the Interscapular White Fat Pad

Published on: March 4, 2020

8.3K

Area of Science:

  • Oncology
  • Animal Models
  • Carcinogenesis

Background:

  • Mammary cancer affects over 500,000 women globally each year.
  • Current treatments for mammary cancer are often ineffective and cause severe side effects.
  • Understanding mammary cancer's biopathology is crucial for developing novel therapies.

Purpose of the Study:

  • To provide an overview of rat models used in mammary cancer research.
  • To emphasize the utility of chemically-induced rat models in studying mammary carcinogenesis.
  • To highlight the importance of animal models in advancing cancer research.

Main Methods:

  • Review of existing literature on rat models for mammary cancer.
  • Focus on chemically-induced carcinogenesis models in rats.
  • Analysis of the application of these models in understanding cancer development.

Main Results:

  • Rat models, particularly chemically-induced ones, are valuable tools for studying mammary carcinogenesis.
  • These models facilitate research into the complex biological mechanisms of mammary cancer.
  • The review synthesizes information on various rat models relevant to mammary cancer.

Conclusions:

  • Chemically-induced rat models are essential for advancing the study of mammary cancer.
  • Further research using these models can lead to improved therapeutic strategies.
  • Rodent models play a critical role in preclinical cancer research.