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Decreased expression of Sema3A, an immune modulator, in blood sample of multiple sclerosis patients

Mahsa Rezaeepoor1, Shima Shapoori1, Mazdak Ganjalikhani-Hakemi1

  • 1Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Gene
|February 12, 2017
PubMed

Insights

Semaphorin 3A (Sema3A) levels are lower in patients with relapsing-remitting multiple sclerosis (RRMS). This immune modulator may play a role in RRMS pathogenesis and could serve as a diagnostic biomarker.

Area of Science:

  • Neuroimmunology
  • Immunology
  • Autoimmune Diseases

Background:

  • Semaphorin 3A (Sema3A) is recognized for its role as an immune modulator.
  • Its involvement in the pathogenesis of autoimmune diseases is increasingly evident.
  • Understanding Sema3A's function in multiple sclerosis (MS) is crucial.

Purpose of the Study:

  • To investigate Sema3A expression in peripheral blood mononuclear cells (PBMCs).
  • To determine serum levels of Sema3A in patients with relapsing-remitting multiple sclerosis (RRMS).
  • To assess the potential of Sema3A as a diagnostic biomarker for RRMS.

Main Methods:

  • Studied fifteen newly diagnosed, untreated RRMS patients during relapsing and remitting phases.
  • Compared RRMS patients with fifteen healthy individuals.
  • Analyzed Sema3A expression in PBMCs and serum levels.
  • Utilized Receiver Operating Characteristic (ROC) analysis to evaluate predictive value.

Main Results:

  • Serum Sema3A levels were significantly lower in RRMS patients compared to healthy controls.
  • Sema3A expression in PBMCs was also significantly reduced in RRMS patients.
  • ROC analysis indicated a potential predictive value for down-regulated Sema3A.

Conclusions:

  • Sema3A down-regulation is observed in RRMS patients.
  • Sema3A may be implicated in the pathogenesis of multiple sclerosis.
  • Sema3A presents potential as a diagnostic biomarker for RRMS.
Keywords:
Autoimmune diseaseImmune modulatorMultiple sclerosisSemaphorin 3A

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