Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunoregulation in Heymann nephritis. II. Functional studies.

J Cornish1, A Z Barabas, R Lannigan

  • 1Department of Pathology, University of Calgary, Alberta, Canada.

British Journal of Experimental Pathology
|October 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Moondance Bowel Cancer Project schools initiative.

Annals of the Royal College of Surgeons of England·2021
Same author

Where have all the appendicectomies gone?

Annals of the Royal College of Surgeons of England·2021
Same author

Correction to: The management of adult appendicitis during the COVID‑19 pandemic: an interim analysis of a UK cohort study.

Techniques in coloproctology·2020
Same author

The management of adult appendicitis during the COVID-19 pandemic: an interim analysis of a UK cohort study.

Techniques in coloproctology·2020
Same author

Safe management of surgical smoke in the age of COVID-19.

The British journal of surgery·2020
Same author

Altered N-methyl D-aspartate receptor subunit expression causes changes to the circadian clock and cell phenotype in osteoarthritic chondrocytes.

Osteoarthritis and cartilage·2018

This study investigated immune cells in Heymann nephritis (HN), a rat model for human membranous glomerulonephropathy. Researchers found immune deregulation during HN induction, with recovery in later stages.

Area of Science:

  • Immunology
  • Nephrology
  • Autoimmune disease research

Background:

  • Heymann nephritis (HN) is a rat model mirroring human membranous glomerulonephropathy (MGN).
  • The autoimmune model is induced by injecting renal tubular antigen (RTA) with Freund's complete adjuvant (FCA).

Purpose of the Study:

  • To investigate the functional properties of immune cells in immunoregulation during Heymann nephritis.
  • To understand the cellular and serological factors contributing to immune deregulation in HN.

Main Methods:

  • Cell marker analyses to assess B cell and plasma cell responses.
  • Evaluation of T cell populations and their functional responses (proliferation, IL-2 production).
  • Investigation of antigen-specific and non-specific immune responses.

Related Experiment Videos

Main Results:

  • A predominantly antigen-non-specific B cell and plasma cell response was observed in the chronic phase of HN.
  • Significant immune deregulation occurred during HN induction, marked by decreased T cell proliferation and IL-2 production.
  • Both cellular defects and inhibitory serological factors contributed to the immune deregulation.

Conclusions:

  • The immune response in HN involves antigen-non-specific B cell activation and T cell deregulation.
  • Defective cellular components and serological factors impair the immune response during HN induction.
  • Immune aberrations in HN gradually normalize in the chronic phase.