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Postmortem studies on mitochondria in schizophrenia.

Rosalinda C Roberts1

  • 1Department of Psychiatry and Behavioral Neurobiology, University of Alabama, Birmingham, AL 35294, United States.

Schizophrenia Research
|February 13, 2017
PubMed
Summary
This summary is machine-generated.

Mitochondrial abnormalities are prevalent in schizophrenia, with reduced numbers observed in specific brain regions and cell types. These changes vary based on brain area, cell type, and treatment response in schizophrenia patients.

Keywords:
Cytochrome oxidaseElectron microscopyNeuropathologyPostmortemPsychosis

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Psychiatry

Background:

  • Mitochondrial dysfunction is increasingly implicated in the pathophysiology of schizophrenia.
  • Previous studies indicate genetic, proteomic, and enzymatic abnormalities associated with mitochondria in schizophrenia.

Purpose of the Study:

  • To review mitochondrial structure-function relationships.
  • To examine ultrastructural abnormalities of mitochondria in postmortem brain tissue from individuals with schizophrenia.

Main Methods:

  • Review of literature on mitochondrial structure and function.
  • Analysis of postmortem brain tissue from schizophrenia subjects, focusing on ultrastructure.
  • Examination of mitochondrial morphology, number, and density in various brain regions (cortex, basal ganglia).

Main Results:

  • A 43% decrease in mitochondria per neuronal soma in the anterior cingulate cortex (layers 5/6) in schizophrenia.
  • Reduced mitochondrial numbers in synaptic terminals in treatment-responsive schizophrenia.
  • Differential effects of schizophrenia on mitochondria depending on brain region, cell type, and treatment status.

Conclusions:

  • Mitochondrial pathology is a significant feature of schizophrenia, exhibiting regional and cellular specificity.
  • Mitochondrial density and number are altered in specific brain areas, correlating with clinical presentation and treatment response in schizophrenia.