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TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
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Strong tissue glue with tunable elasticity.

Regina Kelmansky1, Brian J McAlvin2, Abraham Nyska3

  • 1Faculty of Biotechnology and Food Engineering, Technion, Haifa 32000, Israel.

Acta Biomaterialia
|February 13, 2017
PubMed
Summary
This summary is machine-generated.

Researchers developed new water-free liquid polymers that solidify into strong, elastic tissue sealants. These biocompatible materials offer tunable adhesion, potentially replacing sutures and staples in biomedical applications.

Keywords:
Biomedical applicationsHydrogelsPolymeric materialsTissue adhesives

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Existing bio-adhesives often have weak adhesion or poor biocompatibility.
  • Hydrogels suffer from low strength, while cyanoacrylates exhibit poor elasticity and biocompatibility.
  • There is a need for advanced tissue sealants with tunable mechanical properties and excellent biocompatibility.

Purpose of the Study:

  • To develop novel, water-free liquid polymers that form strong, elastic tissue adhesives upon mixing.
  • To investigate the adhesive properties, mechanical characteristics, and biocompatibility of these new materials.
  • To assess the in vivo retention and inflammatory response of the developed sealant.

Main Methods:

  • Synthesis of four-armed polyethylene glycol (PEG) pre-polymers with NHS or NH2 end groups.
  • Formulation of liquid mixtures with varying concentrations of PEG4-NHS.
  • Evaluation of adhesive strength, elastic modulus, and cytotoxicity in vitro.
  • Assessment of in vivo subcutaneous retention and tissue response for up to 14 days.

Main Results:

  • Liquid PEG pre-polymers transformed into elastic solids upon mixing.
  • Adhesive properties improved with increased PEG4-NHS concentration, reaching levels comparable to cyanoacrylate glues.
  • Minimal cytotoxicity was observed in vitro for all mixtures.
  • 90%v/v PEG4-NHS mixtures demonstrated retention for up to 14 days in vivo with minimal inflammation.

Conclusions:

  • Developed water-free PEG-based pre-polymers form strong, elastic tissue adhesives with tunable properties.
  • The material exhibits excellent biocompatibility and suitable mechanical characteristics for biomedical applications.
  • This novel sealant presents a promising alternative to traditional methods like sutures and staples.