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Updated: Mar 7, 2026

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium
Published on: December 17, 2018
A new isoindoline-based highly selective "turn-on" fluorescent chemodosimeter for detection of mercury ion
Hassan Zali-Boeini1, Mohammad Zareh Jonaghani1, Negar Fadaei1
1Department of Chemistry, University of Isfahan, 81746-73441 Isfahan, Iran.
Abstract:
A new isoindoline-based highly efficient turn-on fluorescent chemodosimeter S with a thioamide functionality as a binding site for selective detection of Hg2+ ion has been developed. The chemodosimeter S showed an extreme selectivity for detection of Hg2+ ion among various two and three-valent metal ions in acetonitrile/water (70/30, v/v). It was found that, in the presence of Hg2+ ion the non-fluorescent chemodosimeter S was efficiently and rapidly desulfurized to the corresponding highly fluorescent amide 1. A good linear relationship was shown between the fluorescence intensity and the concentration of Hg2+ within the range of 0-1μM, with a detection limit of 2.03×10-8M.
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