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Onset of bladder and motor symptoms in multiple system atrophy: differences according to phenotype
Jinhua Zheng1, Xinglong Yang1, Yalan Chen1
1Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, People's Republic of China.
Purpose:
To compare the order of presentation of bladder and motor symptoms between multiple system atrophy phenotypes.
Methods:
Medical records were retrospectively reviewed in 144 patients.
Results:
Bladder symptoms occurred either before or within 12 months after onset of motor symptoms in significantly more patients with the cerebellar phenotype than the parkinsonian phenotype (80 vs. 53%, p = 0.003); similar results were observed for urinary incontinence (79 vs. 45%, p = 0.001).
Conclusions:
Urinary dysfunction is more likely to appear either before or shortly after motor symptoms in the cerebellar phenotype than in the parkinsonian phenotype.
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