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Preserving brain function in a comatose patient with septic hyperpyrexia (41.6 °C): a case report
Samantha Sterkel1, Akinboyede Akinyemi2, Marcos A Sanchez-Gonzalez3
1Department of Internal Medicine, Larkin Community Hospital, Graduate Medical Education, 7000 SW 62nd Avenue, Suite 401, South Miami, FL, 33142, USA.
Journal of Medical Case Reports
|February 14, 2017
Summary
Hyperpyrexia can cause neurodegeneration and cognitive decline. A combination of levetiracetam and amantadine showed neuroprotective effects, restoring neurocognitive function in a patient with severe hyperpyrexia and altered mental status.
Area of Science:
- Neuroscience
- Immunology
- Critical Care Medicine
Background:
- Pyrexia is an immune response to infection, while hyperpyrexia (extremely high body temperature) can cause neurodegeneration.
- Neurotoxic effects of hyperpyrexia include seizures, cognitive decline, coma, and death.
- Clinical management focuses on treating the cause and preventing organ damage.
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