Overview of BioBank Japan follow-up data in 32 diseases

Area of Science:

• Population health
• Biobanking
• Survival analysis

Background:

• Established BioBank Japan with data from ~200,000 patients across 47 common diseases.
• Focused on 32 diseases with poor prognosis, collecting survival and cause of death data.
• Aimed to provide an overview of patient survival data within BioBank Japan.

Purpose of the Study:

• To conduct a comprehensive survival analysis of patients within BioBank Japan.
• To assess survival rates across various common diseases.
• To identify factors influencing patient prognosis and mortality.

Main Methods:

• Included 141,612 participants with survival data last updated in 2014.
• Performed Kaplan-Meier survival analysis, stratified by sex, age, and disease status.
• Estimated relative survival rates using Japanese general population data.

Main Results:

• Followed 141,612 subjects for 1,087,434 person-years, with a 97.0% follow-up rate.
• 35,482 deaths occurred; 5-year and 10-year relative survival rates were 0.944 and 0.911.
• Pancreatic cancer showed the poorest prognosis (10-year relative survival: 0.184), while dyslipidemia had the best (1.013). Malignant neoplasms were the leading cause of death.

Conclusions:

• This study presents the first follow-up survival analysis across multiple common diseases.
• Highlights the need for detailed clinical and genomic data to predict mortality.
• Emphasizes the potential for personalized medicine in managing common diseases.