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Updated: Mar 7, 2026

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

Switching off malignant mesothelioma: exploiting the hypoxic microenvironment.

Noushin Nabavi¹, Kevin L Bennewith², Andrew Churg³

¹Laboratory for Advanced Genome Analysis, Vancouver Prostate Centre, BC, Canada; Department of Urologic Sciences, University of British Columbia, BC, Canada; Department of Experimental Therapeutics, BC Cancer Agency, BC, Canada.

|February 14, 2017

Summary

Malignant mesotheliomas are aggressive asbestos-related cancers. Targeting their genomic pathways, especially within the hypoxic tumor microenvironment, offers a novel therapeutic strategy for this challenging disease.

Keywords:

DNA damage angiogenesis cell cycle hypoxia mesothelioma metabolism proteolysis solid tumors

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Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

Area of Science:

Oncology
Cancer Biology
Genomics

Background:

Malignant mesotheliomas are aggressive, asbestos-related cancers with poor prognosis.
Unspecific symptoms, misdiagnoses, and lack of targeted therapies necessitate further research.
Tumor hypoxia is a known factor in treatment resistance for solid tumors.

Purpose of the Study:

To categorize genomic aberrations in mesotheliomas by canonical pathways.
To discuss therapeutic targeting of these pathways in the context of tumor hypoxia.
To explore the potential of the hypoxic microenvironment as a therapeutic vulnerability.

Main Methods:

Review of existing literature on mesothelioma genomics.
Analysis of canonical pathways associated with identified genomic aberrations.
Discussion of therapeutic strategies targeting these pathways and tumor hypoxia.

Main Results:

Genomic aberrations in mesotheliomas can be categorized into distinct canonical pathways.
Tumor hypoxia significantly impacts treatment resistance in mesotheliomas.
The hypoxic microenvironment presents a potential Achilles' heel for targeted therapies.

Conclusions:

Understanding mesothelioma genomic aberrations and their pathways is crucial.
Targeting these pathways, particularly in the context of hypoxia, may improve therapeutic outcomes.
Exploiting the hypoxic microenvironment offers a promising avenue for multimodal mesothelioma treatment.