Related Experiment Video

Updated: Oct 3, 2026

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

1.3K

Does Garlic Supplementation Control Blood Pressure in Patients with Severe Coronary Artery Disease? A Clinical Trial

Marjan Mahdavi-Roshan1, Javad Nasrollahzadeh1, Ali Mohammad Zadeh2

  • 1Department of Guilan Interventional Cardiovascular Research Center, Heshmat Hospital, Guilan University of Medical Sciences, Rasht, IR Iran.

Iranian Red Crescent Medical Journal
|February 14, 2017
PubMed

Insights

Garlic powder tablets significantly reduced blood pressure (BP) in patients with severe coronary artery disease (CAD). This natural supplement offers a safe adjunctive treatment for managing hypertension in this high-risk group.

Area of Science:

  • Cardiology
  • Nutritional Science
  • Pharmacology

Background:

  • Hypertension is a primary risk factor for cardiovascular diseases, notably coronary artery disease (CAD).
  • Effective management of blood pressure (BP) is crucial in mitigating cardiovascular morbidity.

Purpose of the Study:

  • To evaluate the efficacy of garlic powder tablets in reducing blood pressure (BP) among patients diagnosed with severe coronary artery disease (CAD).
  • To assess the impact of garlic supplementation on blood pressure control in a hypertensive patient cohort with established CAD.

Main Methods:

  • A 3-month randomized, placebo-controlled clinical trial involving 56 patients with severe CAD.
  • Participants received either 400 mg garlic powder tablets twice daily or a placebo, with BP measurements taken at baseline and study conclusion.

Main Results:

  • Garlic supplementation demonstrated a significant reduction in systolic and diastolic blood pressure (BP) compared to placebo in CAD patients.
  • The blood pressure-lowering effect of garlic was more pronounced in hypertensive individuals within the study cohort.
  • No significant alterations in plasma lipids or lipoproteins were observed in either group; tolerability and compliance were high.

Conclusions:

  • Garlic-based treatments show promise as an effective adjunct therapy for controlling blood pressure in patients with coronary artery disease (CAD).
  • Garlic supplementation appears to be a safe option for CAD patients, with no reported interactions with other medications.
  • Garlic may be considered a valuable, natural addition to the management strategy for hypertension in individuals with severe CAD.
Abstract

Keywords:
Coronary Artery DiseaseDiastolic PressureGarlicHypertensionSystolic Pressure

More Related Videos

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

818

Related Concept Videos

Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...