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Related Concept Videos

Primary Lymphoid Organs01:16

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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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Related Experiment Video

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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Composite Diffuse Large B-cell and Mantle Cell Lymphoma: A Case Report.

Farhan Mohammad1, Gwenalyn Garcia1, Shiksha Kedia1

  • 1Department of Hematology and Oncology, Staten Island University Hospital.

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|February 14, 2017
PubMed
Summary

This study reports a rare case of composite lymphoma, a condition with two distinct lymphoma subtypes in one lymph node. The patient had diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) that were clonally unrelated.

Keywords:
compositelymphomar-chop

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Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Composite lymphoma, an exceptionally rare condition, involves the coexistence of two distinct lymphoma subtypes within a single lymph node.
  • This specific combination of diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) is exceedingly uncommon.

Observation:

  • A 57-year-old male presented with leg and groin pain, leading to a biopsy of the right inguinal lymph node.
  • Histopathological examination revealed a mixture of large and small cells.
  • Immunohistochemistry confirmed the presence of DLBCL (large cells) and MCL (small cells).

Findings:

  • Polymerase chain reaction (PCR) analysis demonstrated that the DLBCL and MCL components were clonally unrelated.
  • This represents the third reported case of composite lymphoma with this specific DLBCL and MCL combination in the English literature.

Implications:

  • This case highlights the diagnostic challenges associated with composite lymphoma.
  • Understanding the distinct clonal origins is crucial for accurate diagnosis and effective management strategies.
  • Further research into the pathogenesis and optimal treatment of such rare composite lymphomas is warranted.