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Related Concept Videos

Larynx01:21

Larynx

5.5K
The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids,...
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Related Experiment Video

Updated: Mar 7, 2026

A Heterotopic Mouse Model for Studying Laryngeal Transplantation
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A Heterotopic Mouse Model for Studying Laryngeal Transplantation

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Stem Cell-Based Tissue-Engineered Laryngeal Replacement.

Tahera Ansari1, Peggy Lange1,2, Aaron Southgate1

  • 1Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, United Kingdom.

Stem Cells Translational Medicine
|February 14, 2017
PubMed
Summary
This summary is machine-generated.

This study developed a tissue-engineered larynx scaffold using decellularized porcine larynges and stem cells. The innovative approach shows promise for restoring vocal fold function and improving treatment for laryngeal disorders.

Keywords:
Animal modelHuman stem cellLarynxTissue engineeringTissue scaffold

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Otolaryngology

Background:

  • Laryngeal disorders significantly impact swallowing, vocalization, and respiration.
  • Current therapies for laryngeal defects often yield suboptimal outcomes.
  • Tissue engineering offers a potential solution for restoring laryngeal function and minimizing scarring.

Purpose of the Study:

  • To develop and evaluate a tissue-engineered scaffold for laryngeal reconstruction.
  • To assess the safety and functionality of a decellularized scaffold seeded with stem cells in an animal model.
  • To determine the potential of this approach as an alternative treatment for laryngeal defects.

Main Methods:

  • Porcine larynges were decellularized under Good Laboratory Practice conditions to create an acellular scaffold.
  • The scaffold was seeded with human bone marrow-derived mesenchymal stem cells and a tissue-engineered oral mucosal sheet.
  • The engineered hemilarynx was orthotopically implanted into pigs for 6 months and assessed via imaging, bronchoscopy, and histology.

Main Results:

  • The implanted graft did not adversely affect respiratory function, swallowing, or vocalization.
  • Rudimentary vocal folds covered by contiguous epithelium were successfully regenerated.
  • Histological analysis confirmed scaffold integration and tissue regeneration without significant adverse effects.

Conclusions:

  • Tissue-engineered laryngeal scaffolds represent a viable alternative for treating laryngeal defects.
  • This approach holds potential for restoring vocal fold function and improving patient outcomes.
  • Further clinical trials are warranted to validate the efficacy and safety in humans.