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Cancer Stem Cells Therapeutic Target Database: The First Comprehensive Database for Therapeutic Targets of Cancer

Xiaoqing Hu1, Ye Cong1, Huizhe Howard Luo1

  • 1Center for Molecular Medicine, School of Life Science and Biotechnology, Dalian University of Technology, Dalian, People's Republic of China.

Stem Cells Translational Medicine
|February 14, 2017
PubMed

Insights

Cancer stem cells (CSCs) drive tumor growth and therapy failure. The new Cancer Stem Cells Therapeutic Target Database (CSCTT) offers a vital resource for identifying and developing novel CSC-directed cancer therapies.

Area of Science:

  • Oncology
  • Bioinformatics
  • Cancer Stem Cell Research

Background:

  • Cancer stem cells (CSCs) possess self-renewal and contribute to therapeutic resistance.
  • Targeting CSCs offers a promising strategy for eradicating tumors.
  • Limited validated targets hinder the development of CSC-directed therapies.

Purpose of the Study:

  • To introduce the Cancer Stem Cells Therapeutic Target Database (CSCTT).
  • To provide a comprehensive bioinformatics resource for CSC therapeutic targets.
  • To facilitate the development of novel CSC-directed therapeutics.

Main Methods:

  • Manual curation of experimental evidence from literature.
  • Compilation of protein targets, their annotations, and therapeutic methods.
  • Development of an online database for data display, search, and analysis.

Main Results:

  • CSCTT includes 135 potential CSC protein targets with validated experimental evidence.
  • Proteins are annotated with family, function, disease relevance, and evidence.
  • The database contains 213 documented therapeutic methods, including small molecules and biotherapies.

Conclusions:

  • CSCTT is the first online database for CSC therapeutic targets.
  • It serves as a valuable platform for developing CSC-directed therapeutics.
  • The database is publicly accessible at http://www.csctt.org/.

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