Diagnostic Validity Comparison Between Criteria Based on CSF Alzheimer's Disease Biomarkers
Maria Empar Blanco-Cantó1, J A Monge-Argilés1, C Pérez-Cejuela2
11 Department of Neurology, General University Hospital of Alicante, Alicante, Spain.
Aim:
To compare the diagnostic validity of NIA-AA criteria, for AD CSF biomarkers, with our own new criteria.
Materials And Methods:
Between 2008 and 2011, 170 patients with Mild Cognitive Impairment (MCI) were included. CSF levels of Aβ1-42, T-tau, P-tau181, and ratios of T-tau/Aβ1-42 and P-tau181/Aβ1-42 were analyzed. In our criteria, we considered 3 or more abnormal variables indicative of a high likelihood of MCI due to AD.
Results:
After a clinical follow-up of 4.5 ± 1.2 years, 44 patients remained stable, 95 developed AD, 15 other forms of dementia, 7 died and 9 received other diagnoses. Using the NIA-AA criteria and our own criteria, the diagnostic validity of the CSF biomarkers was 58% versus 85%, specificity 84% versus 72%, PPV 82% versus 79% and NPV 61% versus 79%.
Conclusion:
The inclusion of the ratios in diagnostic criteria increases sensitivity and NPV for the diagnosis of MCI due to AD.
