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Related Experiment Video

Updated: Mar 7, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
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Optical coherence tomography segmentation analysis in relapsing remitting versus progressive multiple sclerosis.

Raed Behbehani1,2, Abdullah Abu Al-Hassan1, Ali Al-Salahat1

  • 1Al-Bahar Ophthalmology Center, Ibn Sina Hospital, Kuwait City, Kuwait.

Plos One
|February 14, 2017
PubMed
Summary
This summary is machine-generated.

Progressive MS patients show more retinal layer thinning than relapsing-remitting MS patients. Specific retinal layer changes correlate with disease severity, indicating different disease mechanisms.

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Medical Imaging

Background:

  • Optical coherence tomography (OCT) with retinal segmentation analysis is crucial for in-vivo imaging of neurodegeneration in multiple sclerosis (MS).
  • Deep retinal layer involvement is observed in MS, with potential differences between MS phenotypes.
  • Limited data exists on deeper retinal layer changes in progressive MS (PMS) versus relapsing-remitting MS (RRMS).

Purpose of the Study:

  • To compare OCT segmentation analysis between patients with RRMS and PMS.
  • To investigate the pattern of deeper retinal layer involvement in different MS phenotypes.

Main Methods:

  • A cross-sectional study involving 113 MS patients (29 PMS, 84 RRMS) and 38 healthy controls.
  • Spectral domain OCT (SDOCT) was used with a macular cube acquisition protocol.
  • Retinal layer segmentation was performed using Orion software to quantify layer thicknesses.

Main Results:

  • Significant thinning of the retinal nerve fiber layer (RNFL), ganglion-cell/inner plexiform layer (GCIPL), and outer plexiform layer (OPL) was observed in PMS compared to RRMS.
  • A negative correlation between the outer nuclear layer (ONL) and EDSS was found in PMS patients.
  • In RRMS patients with prior optic neuritis, GCIPL showed a negative correlation, while the photoreceptor layer (PR) showed a positive correlation with EDSS.

Conclusions:

  • PMS patients exhibit greater atrophy in both inner and outer retinal layers compared to RRMS patients.
  • The ONL in PMS and GCIPL and PR in RRMS may serve as surrogate markers for disease burden and progression (EDSS).
  • Differential retinal layer involvement and its correlation with disability suggest distinct pathophysiologic mechanisms and progression stages in MS.