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Published on: August 28, 2018
Absence of association between gallstone and coronary artery calcification
Chang Hee Kwon1, Jung Gyu Kang2, Hyun Jong Lee3
1Division of Cardiology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea.
Insights
Gallstone presence was not linked to coronary artery calcification (CAC) in a large Korean occupational cohort. This study found no significant association between gallstones and cardiovascular disease risk markers in men or women.
Area of Science:
- Cardiology
- Epidemiology
- Gastroenterology
Background:
- Gallstones are a common condition.
- Cardiovascular disease (CVD) remains a leading cause of mortality worldwide.
- Coronary artery calcification (CAC) is a validated predictor of future CVD events.
Purpose of the Study:
- To investigate the potential association between gallstone disease and the presence of coronary artery calcification (CAC).
- To determine if gallstones serve as a risk factor for subclinical atherosclerosis, as indicated by CAC.
Main Methods:
- Analysis of data from a large occupational cohort (46,893 participants) from 2011-2014.
- Exclusion of participants with prior cancer, CVD, or incomplete baseline data.
- Diagnosis of gallstone via ultrasound and assessment of CAC; multivariate logistic regression used to analyze the gallstone-CAC relationship.
Main Results:
- Gallstones were identified in 3.1% (1426) of the study population.
- Multivariate analysis revealed no significant difference in odds ratios for gallstone presence across different CAC score groups in both men and women.
- Gallstone disease was not found to be independently associated with higher odds of CAC in either sex.
Conclusions:
- The study concludes that gallstone disease is not associated with coronary artery calcification in the studied Korean population.
- Findings suggest that gallstones may not be a significant risk factor for subclinical atherosclerosis in this cohort.
Background And Aims:
Gallstone has been suggested to be associated with cardiovascular disease (CVD). Coronary artery calcification (CAC) is an excellent value to predict future CVD. The aim of this study was to evaluate the association between gallstone and CAC.
Methods:
Data were analyzed from an occupational cohort of 46,893 subjects (37,557 men and 9336 women) between 2011 and 2014. Participants with cancer or CVD histories or missing data at baseline were excluded from the study. Gallstone was diagnosed by ultrasound-documentation. Multivariate logistic analysis was conducted to examine the relationship between gallstone and CAC.
Results:
The total population who had gallstone was 1426 (3.1%). In multivariate analysis, odds ratios (OR) for gallstone were not different according to CAC score groups in men and women. In addition, gallstone was not associated with higher OR for CAC in men and women.
Conclusions:
Gallstone was not associated with CAC in both Korean men and women.
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