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Related Concept Videos

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Related Experiment Video

Updated: Feb 28, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
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Cicatrical Pemphigoid.

J S Pasricha, Ramji Gupta, U N Bhuyan

    Indian Journal of Dermatology, Venereology and Leprology
    |February 15, 2017
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    Summary
    This summary is machine-generated.

    This case report details the first instance of cicatricial pemphigoid in India. The patient presented with oral vesicles, skin blisters healing by scarring, and ocular symblepharon, with negative IgG antibody tests.

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    Granulocyte-dependent Autoantibody-induced Skin Blistering
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    Area of Science:

    • Dermatology
    • Ophthalmology
    • Immunology

    Background:

    • Cicatricial pemphigoid is a rare, chronic autoimmune blistering disease.
    • It primarily affects mucous membranes and skin, potentially leading to scarring and significant morbidity.
    • This report documents the initial presentation of this condition in India.

    Observation:

    • A 58-year-old male developed tense, dome-shaped oral vesicles.
    • Subsequently, he experienced skin blisters that healed with scarring.
    • Ocular complications, specifically symblepharon, appeared 23 months after disease onset.

    Findings:

    • Histological examination revealed a subepidermal split.
    • Direct immunofluorescence testing for IgG antibodies in the patient's serum was negative.
    • The clinical presentation and histological findings are consistent with cicatricial pemphigoid.

    Implications:

    • This case highlights the importance of recognizing cicatricial pemphigoid in diverse geographic regions.
    • Early diagnosis and management are crucial to prevent severe scarring and functional impairment, particularly in ocular tissues.
    • Further research is warranted to understand the specific triggers and immunopathogenesis in the Indian population.