Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

1.8K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.8K
Fatigue01:21

Fatigue

907
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
907
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

4.6K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
4.6K
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.6K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.6K
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

76
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
76
Factors Affecting Illness01:18

Factors Affecting Illness

5.6K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Insights from a methylome-wide association study of antidepressant exposure.

Nature communications·2025
Same author

Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants.

Molecular psychiatry·2024
Same author

Antidepressant Exposure and DNA Methylation: Insights from a Methylome-Wide Association Study.

medRxiv : the preprint server for health sciences·2024
Same author

Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants.

medRxiv : the preprint server for health sciences·2024
Same author

Three major dimensions of human brain cortical ageing in relation to cognitive decline across the eighth decade of life.

Molecular psychiatry·2021
Same author

Psychosocial factors and hospitalisations for COVID-19: Prospective cohort study based on a community sample.

Brain, behavior, and immunity·2020

Related Experiment Video

Updated: Mar 7, 2026

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

20.4K

Genetic contributions to self-reported tiredness.

V Deary1, S P Hagenaars2,3,4, S E Harris2,5

  • 1Department of Psychology, Northumbria University, Newcastle, UK.

Molecular Psychiatry
|February 15, 2017
PubMed
Summary
This summary is machine-generated.

Tiredness, or fatigue, is partly heritable and linked to physical and mental health. A large genome-wide study found genetic links between fatigue and conditions like obesity, depression, and heart disease.

More Related Videos

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.7K
Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

6.3K

Related Experiment Videos

Last Updated: Mar 7, 2026

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

20.4K
Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.7K
Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

6.3K

Area of Science:

  • Genetics
  • Psychiatry
  • Epidemiology

Background:

  • Self-reported tiredness and low energy (fatigue) are linked to poorer physical and mental health outcomes.
  • Previous twin studies suggest a heritability for fatigue ranging from 6% to 50%.

Purpose of the Study:

  • To conduct a genome-wide association study (GWAS) for self-reported tiredness.
  • To investigate the genetic overlap between tiredness and various physical and mental health traits.

Main Methods:

  • Utilized UK Biobank data from 108,976 individuals for a GWAS on tiredness.
  • Employed GCTA-GREML to estimate heritability and linkage disequilibrium score regression for genetic correlations.
  • Conducted polygenic profile score analyses to assess shared genetic etiology.

Main Results:

  • Identified one genome-wide significant genetic hit for tiredness.
  • Found significant genetic correlations between tiredness and traits including BMI, obesity, type 2 diabetes, major depressive disorder, and schizophrenia.
  • Detected associations between tiredness and polygenic scores for numerous health and cognitive traits.

Conclusions:

  • Tiredness is a complex, heterogeneous trait with partial heritability.
  • Fatigue shares genetic underpinnings with affective, cognitive, personality, and physiological factors.
  • These findings highlight the biological basis of fatigue and its connections to various health conditions.