Intriguing Morphology of IgG/Lambda Secreting Myeloma Cells

Area of Science:

• Hematopathology
• Oncology
• Cell Biology

Background:

• Plasma cells in multiple myeloma exhibit diverse morphologies.
• Inclusions within myeloma cells are common, but resemblance to storage histiocytes is rare.
• Previous reports noted pseudo-Gaucher cells in myeloma, but not myeloma cells themselves appearing as storage cells.

Purpose of the Study:

• To document and illustrate the uncommon morphology of plasma cells resembling storage cells in multiple myeloma.
• To highlight the importance of recognizing atypical plasma cell morphology in diagnosing myeloma.
• To increase awareness among hematopathologists regarding unusual presentations of plasma cell neoplasms.

Main Methods:

• Morphological examination of plasma cells from a patient with IgG/lambda plasma cell myeloma.
• Photographic documentation of the distinct cellular morphology.
• Review of relevant literature on myeloma cell morphology and inclusions.

Main Results:

• Observed plasma cells with features characteristic of storage histiocytes.
• Confirmed diagnosis of IgG/lambda plasma cell myeloma.
• The atypical morphology was noted in the context of the overall myeloma presentation.

Conclusions:

• Plasma cells in multiple myeloma can present with morphology mimicking storage histiocytes.
• Hematopathologists should consider this unusual presentation, especially in extramedullary plasmacytomas.
• Recognition of varied plasma cell morphology is essential for accurate diagnosis and patient management.