Related Experiment Video
Updated: Mar 7, 2026
08:29
Analyses of Mitochondrial Calcium Influx in Isolated Mitochondria and Cultured Cells
Published on: April 27, 2018
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The Mitochondrial Ca2+ Uniporter: Structure, Function, and Pharmacology
Jyotsna Mishra1, Bong Sook Jhun2, Stephen Hurst1
1Center for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, 1020 Locust Street, Suite 543D, Philadelphia, PA, 19107, USA.
Handbook of Experimental Pharmacology
|February 15, 2017
Summary
Mitochondrial calcium uptake is vital for cell function, but imbalances can cause cell death. This chapter reviews mitochondrial calcium uptake, homeostasis, and the key components of the mitochondrial calcium uniporter complex.
Area of Science:
- Cellular Biology
- Mitochondrial Physiology
- Biochemistry
Background:
- Mitochondrial calcium (Ca2+) uptake plays a critical role in cellular functions.
- Dysregulation of mitochondrial Ca2+ homeostasis is implicated in various pathophysiological conditions and cell death.
- Understanding mitochondrial Ca2+ dynamics is essential for comprehending cell physiology.
Purpose of the Study:
- To review the diverse mechanisms of mitochondrial Ca2+ uptake.
- To elucidate the current understanding of mitochondrial Ca2+ homeostasis in health and disease.
- To focus on the molecular components, regulators, and pharmacology of the mitochondrial Ca2+ uniporter complex.
Main Methods:
- Literature review of mitochondrial Ca2+ uptake mechanisms.
- Analysis of current research on mitochondrial Ca2+ homeostasis.
- Detailed examination of the mitochondrial Ca2+ uniporter complex.
Main Results:
- Overview of various mitochondrial Ca2+ uptake pathways.
- Summary of the established knowledge on mitochondrial Ca2+ regulation.
- Identification of key molecular players within the mitochondrial Ca2+ uniporter complex.
Conclusions:
- Mitochondrial Ca2+ uptake is a tightly regulated process crucial for cellular viability.
- Imbalances in mitochondrial Ca2+ handling contribute to cellular dysfunction and death.
- Further research into the mitochondrial Ca2+ uniporter complex offers therapeutic potential.
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