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Host Materials Transformable in Tumor Microenvironment for Homing Theranostics.

Pei-Pei Yang1, Qiang Luo1,2, Guo-Bin Qi1

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Advanced Materials (Deerfield Beach, Fla.)
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A novel nanosystem transforms into nest-like structures in acidic tumor environments. This strategy enhances the accumulation and stabilization of theranostics for effective tumor treatment.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Developing effective drug delivery systems for solid tumors remains a challenge.
  • Targeted delivery of theranostics (diagnostic and therapeutic agents) is crucial for cancer treatment.
  • Tumor microenvironment (TME) characteristics, such as acidity, can be exploited for drug delivery.

Purpose of the Study:

  • To develop a pathology-adaptive nanosystem for enhanced theranostics delivery to solid tumors.
  • To investigate the transformation of nanoparticles into nest-like hosts within the acidic TME.
  • To evaluate the efficiency of tumor modification and theranostics accumulation using this nanosystem.

Main Methods:

  • Intravenous (i.v.) injection of nanoparticles designed to self-assemble.
  • Utilizing the acidic tumor microenvironment to trigger nanoparticle transformation into nanofibers and nest-like hosts.
  • Assessing the accumulation and stabilization of theranostics within the modified tumor tissue.

Main Results:

  • The nanosystem successfully transformed into nest-like hosts under acidic conditions.
  • The solid tumor was effectively and firmly modified by these hosts.
  • Highly efficient accumulation and stabilization of guest theranostics within the tumor were achieved.

Conclusions:

  • The pathology-adaptive nanosystem demonstrates a promising strategy for theranostics delivery.
  • Exploiting the acidic TME for nanosystem self-assembly offers a novel approach to tumor targeting.
  • This approach holds significant potential for improving cancer theranostics efficacy.