Related Experiment Video
Updated: Mar 7, 2026

Assessing Dominant-Submissive Behavior in Adult Rats Following Traumatic Brain Injury
Published on: December 16, 2022
The Relations of Cognitive, Behavioral, and Physical Activity Variables to Depression Severity in Traumatic Brain
Charles H Bombardier1, Jesse R Fann, Evette J Ludman
1Department of Rehabilitation Medicine, University of Washington, Seattle (Drs Bombardier and Dyer); Departments of Psychiatry and Behavioral Sciences, Rehabilitation Medicine and Epidemiology, University of Washington, Seattle (Dr Fann); Group Health Research Institute, Seattle, Washington (Dr Ludman); Counseling and School Psychology, University of Massachusetts, Boston (Dr Vannoy); Department of Neurological Surgery, University of Washington, Seattle (Mr Barber); and Department of Neurological Surgery and Biostatistics, University of Washington, Seattle (Dr Temkin).
Objective:
To explore the relations of cognitive, behavioral, and physical activity variables to depression severity among people with traumatic brain injury (TBI) undergoing a depression treatment trial.
Setting:
Community.
Participants:
Adults (N = 88) who sustained complicated mild to severe TBI within the past 10 years, met criteria for major depressive disorder, and completed study measures.
Design:
Randomized controlled trial.
Methods:
Participants were randomized to cognitive-behavioral therapy (n = 58) or usual care (n = 42). Outcomes were measured at baseline and 16 weeks. We combined the groups and used regressions to explore the relations among theoretical variables and depression outcomes.
Main Measures:
Depression severity was measured with the Hamilton Depression Rating Scale and Symptom Checklist-20. Theory-based measures were the Dysfunctional Attitudes Scale (DAS), Automatic Thoughts Questionnaire (ATQ), Environmental Rewards Observation Scale (EROS), and the International Physical Activity Questionnaire (IPAQ).
Results:
Compared with non-TBI norms, baseline DAS and ATQ scores were high and EROS and IPAQ scores were low. All outcomes improved from baseline to 16 weeks except the DAS. The ATQ was an independent predictor of baseline depression. An increase in EROS scores was correlated with decreased depression.
Conclusions:
Increasing participation in meaningful roles and pleasant activities may be a promising approach to treating depression after TBI.
Related Concept Videos
Cognitive Therapy
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Post-traumatic Stress Disorder
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...

