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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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Wellens' Syndrome: A Bad Omen.

Madalena Coutinho Cruz1, Isabel Luiz, Lurdes Ferreira

  • 1Cardiology Department, Hospital de Santa Marta, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.

Cardiology
|February 15, 2017
PubMed
Summary

Wellens

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Wellens' syndrome indicates critical left anterior descending artery stenosis.
  • It often precedes extensive anterior myocardial infarction.

Observation:

  • Two cases illustrate the varied presentation of Wellens' syndrome.
  • One patient had atypical chest pain and biphasic T waves, managed medically.
  • Another presented with typical angina, biphasic T waves, and positive troponin, treated with PCI.

Findings:

  • ECG T-wave changes, particularly biphasic T waves, are key indicators.
  • Fractional flow reserve and cardiac biomarkers aid diagnosis.
  • Treatment strategies vary based on clinical presentation and stenosis severity.

Implications:

Keywords:
Acute coronary syndromeLeft anterior descending arteryT waveUnstable angina

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  • Early recognition of Wellens' syndrome is crucial for timely intervention.
  • High clinical suspicion is vital, especially for atypical presentations.
  • Prompt diagnosis and treatment can prevent severe cardiac events.