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Related Concept Videos

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
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Related Experiment Video

Updated: Mar 7, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
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Perinatal programming by inflammation.

Sarah J Spencer1, Urs Meyer2

  • 1School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia.

Brain, Behavior, and Immunity
|February 16, 2017
PubMed
Summary
This summary is machine-generated.

Early life exposure to inflammation impacts brain development and behavior, increasing risks for later-life diseases and affecting cognitive function. This research explores perinatal inflammation

Keywords:
Autism spectrum disordersDepressionDevelopmentEarly lifeInflammationPainPerinatal programmingSchizophrenia

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Immunology

Background:

  • Seminal work by Levine and Barker established the critical role of the early life environment.
  • The developing brain exhibits significant plasticity, vulnerability, and resilience to environmental factors.
  • Early exposure to pathogens and inflammation has enduring effects on brain and behavior.

Discussion:

  • Perinatal inflammation influences susceptibility to neuroinflammatory injury and later-life diseases.
  • Impacts extend to cognitive function, emotionality, pain responses, and metabolic health.
  • Challenges exist in modeling complex disorders like autism spectrum disorders and schizophrenia in rodents, particularly with whole-litter manipulations.

Key Insights:

  • Early inflammatory stimuli during the perinatal period can lead to long-lasting alterations in brain structure and function.
  • These changes are linked to increased vulnerability to neurological and psychiatric conditions.
  • Understanding these mechanisms is crucial for developing targeted interventions.

Outlook:

  • This special issue presents the latest research on perinatal inflammation and its programming effects on the brain and behavior.
  • Future research will continue to elucidate the complex interplay between the immune system and brain development.
  • Advances in this field hold promise for preventing and treating neurodevelopmental and psychiatric disorders.